Welcome to SCENIC+’s documentation!

SCENIC+ is a python package to build enhancer driven gene regulatory networks (GRNs) using combined or separate single-cell gene expression (scRNA-seq) and single-cell chromatin accessibility (scATAC-seq) data.

SCENIC+ makes use of several python packages:

• pycisTopic for enhancer candidate identification and topic modeling (read the docs page).

• pycistarget for motif enrichment analysis in enhancer candidates (read the docs page).

• create_cisTarget_databases for creating of custom cistarget databases (github page)

SCENIC+ Flow chart